| Long name: |
Biotin Conjugated, FBXO11 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FBXO11 |
| Specificity: |
This is a highly specific antibody against FBXO11 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
85-127/927 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human FBXO11 |
| Gene ID number: |
80204 |
| Swiss Prot: |
Q86XK2 |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
BCL6 and PRDM1/BLIMP1, Binds to and neddylates phosphorylated p53/TP53, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, inhibiting its transcriptional activity, such as DTL/CDT2, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
FBX11 UBR6 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FBXO11 Conjugated |
| Short name: |
Conjugated, FBXO11 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, FBXO11 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13590 |
| Gene: |
FBXO11 |
More about : FBXO11 |
| Long gene name: |
F-box protein 11 |
| Synonyms gene name: |
F-box only protein 11 |
| Synonyms name: |
ubiquitin protein ligase E3 component n-recognin 6 |
| Locus: |
2p16, 3 |
| Discovery year: |
2000-09-27 |
| GenBank acession: |
AF174599 |
| Entrez gene record: |
80204 |
| Pubmed identfication: |
10531035 16487488 18162545 |
| RefSeq identity: |
NM_012167 NM_018693 NM_025133 |
| Classification: |
F-boxes other Ubiquitin protein ligase E3 component n-recognins |
| Havana BLAST/BLAT: |
OTTHUMG00000129130 |