| Long name: |
ALEXA FLUOR 594 Conjugated, FBXO11 Polyclonal Antibody |
| Also known as: |
Anti-FBXO11 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
FBXO11 |
| Specificity: |
This is a highly specific antibody against FBXO11 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
85-127/927 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FBXO11 |
| Gene ID Number: |
80204 |
| Swiss Prot: |
Q86XK2 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
BCL6 and PRDM1/BLIMP1, Binds to and neddylates phosphorylated p53/TP53, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, inhibiting its transcriptional activity, such as DTL/CDT2, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
FBX11 UBR6 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
FBXO11 |
| Short name: |
FBXO11 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, FBXO11 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13590 |
| Gene: |
FBXO11 |
More about : FBXO11 |
| Long gene name: |
F-box protein 11 |
| Synonyms gene name: |
F-box only protein 11 |
| Synonyms name: |
ubiquitin protein ligase E3 component n-recognin 6 |
| Locus: |
2p16, 3 |
| Discovery year: |
2000-09-27 |
| GenBank acession: |
AF174599 |
| Entrez gene record: |
80204 |
| Pubmed identfication: |
10531035 16487488 18162545 |
| RefSeq identity: |
NM_012167 NM_018693 NM_025133 |
| Classification: |
F-boxes other Ubiquitin protein ligase E3 component n-recognins |
| Havana BLAST/BLAT: |
OTTHUMG00000129130 |