| Long name: |
FBXO11 Primary Polyclonal Antibody |
| Also known as: |
FBXO11 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FBXO11 |
| Specificity: |
This is a highly specific antibody against FBXO11 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
85-127/927 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human FBXO11 |
| Gene ID number: |
80204 |
| Swiss Prot: |
Q86XK2 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
BCL6 and PRDM1/BLIMP1, Binds to and neddylates phosphorylated p53/TP53, SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53, The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit, inhibiting its transcriptional activity, such as DTL/CDT2, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells, Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
F-box only protein 11, FBX11, FBXO11, PRMT9, Protein arginine N-methyltransferase 9, UG063H01, VIT-1, VIT1, Vitiligo-associated protein 1, UBR6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
FBXO11 |
| Short name: |
FBXO11 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FBXO11 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
13590 |
| Gene: |
FBXO11 |
More about : FBXO11 |
| Long gene name: |
F-box protein 11 |
| Synonyms gene name: |
F-box only protein 11 |
| Synonyms: |
FBX11 UBR6 |
| Synonyms name: |
ubiquitin protein ligase E3 component n-recognin 6 |
| Locus: |
2p16, 3 |
| Discovery year: |
2000-09-27 |
| GenBank acession: |
AF174599 |
| Entrez gene record: |
80204 |
| Pubmed identfication: |
10531035 16487488 18162545 |
| RefSeq identity: |
NM_012167 NM_018693 NM_025133 |
| Classification: |
F-boxes other Ubiquitin protein ligase E3 component n-recognins |
| Havana BLAST/BLAT: |
OTTHUMG00000129130 |