| Long name: |
RNF75 Primary Polyclonal Antibody |
| Also known as: |
RNF75 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RNF75 |
| Specificity: |
This is a highly specific antibody against RNF75 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ROC1/RNF75 |
| Gene ID number: |
9978 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation, CUL2, CUL4 and CUL4 via its interaction with UBE2M, May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair, Probably also stimulates CDC34 autoubiquitination, Promotes the neddylation of CUL1, The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components, Through the RING-type zinc finger, including proteins involved in cell cycle progression, like CDC34, seems to recruit the E2 ubiquitination enzyme, signal transduction, to the complex and brings it into close proximity to the substrate, transcription and transcription-coupled nucleotide excision repair, E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
MGC13357, MGC1481, Protein ZYP, RBX1_HUMAN, RING box protein 1, RING finger protein, RING finger protein 75, RING-box protein 1, RNF 75, RNF75, ROC 1, Rbx 1, Rbx1, Regulator of Cullins 1, Ring box 1, Ringbox protein 1, ZYP protein, E3 ubiquitin-protein ligase RBX1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RNF75 |
| Short name: |
RNF75 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RNF75 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9928 |
| Gene: |
RBX1 |
More about : RBX1 |
| Long gene name: |
ring-box 1 |
| Synonyms gene name: |
E3 ubiquitin protein ligase , ring-box 1 ring-box 1 |
| Synonyms: |
ROC1 RNF75 BA554C12, 1 |
| Synonyms name: |
regulator of cullins 1 |
| Locus: |
22q13, 2 |
| Discovery year: |
1999-10-29 |
| GenBank acession: |
AF140598 |
| Entrez gene record: |
9978 |
| Pubmed identfication: |
10213691 10230407 |
| RefSeq identity: |
NM_014248 |
| Classification: |
Ring finger proteins SCF complex |
| Havana BLAST/BLAT: |
OTTHUMG00000151298 |