| Long name: |
ALEXA FLUOR 488 Conjugated, NIPA Polyclonal Antibody |
| Also known as: |
Anti-NIPA PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NIPA |
| Specificity: |
This is a highly specific antibody against NIPA |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NIPA |
| Gene ID Number: |
51530 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry, Nuclear cyclin B1 is a substrate of SCFNIPA, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle, The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, Thus, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry, which restricts substrate ubiquitination activity to interphase, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core, The regulated oscillation of protein expression is an essential mechanism of cell cycle control |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
NIPA |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the NIPA Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
NIPA |
| Short name: |
NIPA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, NIPA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29913 |
| Gene: |
ZC3HC1 |
More about : ZC3HC1 |
| Long gene name: |
zinc finger C3HC-type containing 1 |
| Synonyms name: |
nuclear interaction partner of ALK |
| Locus: |
7q32, 2 |
| Discovery year: |
2004-11-19 |
| GenBank acession: |
AF151050 |
| Entrez gene record: |
51530 |
| Pubmed identfication: |
11042152 |
| RefSeq identity: |
NM_016478 |
| Classification: |
Zinc fingers |
| Havana BLAST/BLAT: |
OTTHUMG00000157648 |