| Long name: |
NIPA Primary Polyclonal Antibody |
| Also known as: |
NIPA PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NIPA |
| Specificity: |
This is a highly specific antibody against NIPA |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NIPA |
| Gene ID number: |
51530 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry, Nuclear cyclin B1 is a substrate of SCFNIPA, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle, The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, Thus, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry, which restricts substrate ubiquitination activity to interphase, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core, The regulated oscillation of protein expression is an essential mechanism of cell cycle control |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NIPA_HUMAN, Nuclear interacting partner of ALK, Nuclear interacting partner of anaplastic lymphoma kinase, ZC3HC1, Zinc finger C3HC type containing 1, hNIPA |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NIPA |
| Short name: |
NIPA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NIPA (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
29913 |
| Gene: |
ZC3HC1 |
More about : ZC3HC1 |
| Long gene name: |
zinc finger C3HC-type containing 1 |
| Synonyms: |
NIPA |
| Synonyms name: |
nuclear interaction partner of ALK |
| Locus: |
7q32, 2 |
| Discovery year: |
2004-11-19 |
| GenBank acession: |
AF151050 |
| Entrez gene record: |
51530 |
| Pubmed identfication: |
11042152 |
| RefSeq identity: |
NM_016478 |
| Classification: |
Zinc fingers |
| Havana BLAST/BLAT: |
OTTHUMG00000157648 |