| Long name: |
Biotin Conjugated, ARRDC4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ARRDC4 |
| Specificity: |
This is a highly specific antibody against ARRDC4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human ARRDC4 |
| Gene ID number: |
91947 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs), Different arrestins (visual arrestin (or Arrestin 1), GPCRs activate a heterotrimeric G protein, In order to turn off this response, In response to a stimulus, Once arrestin is bound to the receptor it is unable to signal further, Recent research continues to expand the known actions of arrestins, The arrestins are a family of proteins that are important for regulating signal transduction within cells, The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs), This phosphorylation specifically marks the activated receptor for arrestin binding, activated receptors need to be silenced, beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways, or adapt to a constant stimulus, which can bind to other classes of receptors and can directly activate signaling pathways on their own, ARRDC4 belongs to the arrestin family |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
FLJ36045 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ARRDC4 Conjugated |
| Short name: |
Conjugated, ARRDC4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, ARRDC4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
28087 |
| Gene: |
ARRDC4 |
More about : ARRDC4 |
| Long gene name: |
arrestin domain containing 4 |
| Locus: |
15q26, 2 |
| Discovery year: |
2004-02-11 |
| GenBank acession: |
BC028704 |
| Entrez gene record: |
91947 |
| Pubmed identfication: |
12477932 |
| RefSeq identity: |
NM_183376 |
| Classification: |
Alpha arrestins |
| Havana BLAST/BLAT: |
OTTHUMG00000149849 |