| Long name: |
ALEXA FLUOR 594 Conjugated, LRDD Polyclonal Antibody |
| Also known as: |
Anti-LRDD PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
LRDD |
| Specificity: |
This is a highly specific antibody against LRDD |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LRDD/PIDD |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, Independently, PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis, PIDD forms a complex with caspase-2 and the adaptor protein RAIDD, PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, PIDD was also described as a DD-containing protein with unknown function, The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, an important component for activation of the transcription factor NF-kappa-B, followed by two ZU-5 domains and a C-terminal DD, via interaction with caspase-2 and CRADD/RAIDD, The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MGC16925 DKFZp434D229 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
LRDD |
| Short name: |
LRDD Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, LRDD (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16491 |
| Gene: |
PIDD1 |
More about : PIDD1 |
| Long gene name: |
p53-induced death domain protein 1 |
| Synonyms gene: |
LRDD PIDD |
| Synonyms gene name: |
leucine-rich repeats and death domain containing p53-induced death domain protein |
| Locus: |
11p15, 5 |
| Discovery year: |
2001-09-04 |
| GenBank acession: |
AF229178 |
| Entrez gene record: |
55367 |
| Pubmed identfication: |
10825539 |
| RefSeq identity: |
NM_145886 |
| Havana BLAST/BLAT: |
OTTHUMG00000133306 |