| Long name: |
Biotin Conjugated, CPB2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CPB2 |
| Specificity: |
This is a highly specific antibody against CPB2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human CPB2 |
| Gene ID number: |
1361 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, Being activated by thrombin-thrombomodulin complex during blood coagulation, Elevated concentration in blood is considered as a risk factor for venous thrombosis, High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease, It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues, The concentration in plasma of healthy people is 5-10 ug/ml, This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot, and decreased levels are found in chronic liver disease, it exerts carboxypeptidase activity, pI 5, which is necessary for plasminogen binding to fibrin, 0), This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
CPU PCPB TAFI |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CPB2 Conjugated |
| Short name: |
Conjugated, CPB2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, CPB2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2300 |
| Gene: |
CPB2 |
More about : CPB2 |
| Long gene name: |
carboxypeptidase B2 |
| Synonyms gene name: |
carboxypeptidase B2 (plasma, carboxypeptidase U) carboxypeptidase B2 (plasma) |
| Synonyms name: |
thrombin-activatable fibrinolysis inhibitor carboxypeptidase U plasma carboxypeptidase B carboxypeptidase R |
| Locus: |
13q14, 13 |
| Discovery year: |
1992-04-10 |
| GenBank acession: |
M75106 |
| Entrez gene record: |
1361 |
| Pubmed identfication: |
1939207 1427879 |
| RefSeq identity: |
NM_001872 |
| Classification: |
Carboxypeptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000016867 |