| Long name: |
ApoER2 Primary Polyclonal Antibody |
| Also known as: |
ApoER2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ApoER2 |
| Specificity: |
This antibody will detect both the membrane bound and the secreted isoform variants of this protein, This is a highly specific antibody against ApoER2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
848-898/963 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ApoER2 |
| Gene ID number: |
7804 |
| Swiss Prot: |
Q14114 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature, Binds the endoplasmic reticulum resident receptor-associated protein (RAP), Highly expressed in the initial segment of the epididymis, LRP8 has higher affinity for Reelin than VLDLR, LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development, LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, May also function as an endocytic receptor, Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons, by binding to DAB1 on its cytoplasmic tail, two proteins required for sperm maturation, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
APOER2, Apolipoprotein E receptor 2, HSZ75190, LRP-8, LRP8, Low-density lipoprotein receptor-related protein 8, MCI1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ApoER2 |
| Short name: |
ApoER2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ApoER2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6700 |
| Gene: |
LRP8 |
More about : LRP8 |
| Long gene name: |
LDL receptor related protein 8 |
| Synonyms gene name: |
apolipoprotein e receptor , low density lipoprotein receptor-related protein 8 |
| Synonyms: |
APOER2 MCI1 LRP-8 HSZ75190 |
| Locus: |
1p32, 3 |
| Discovery year: |
1998-08-13 |
| GenBank acession: |
D50678 |
| Entrez gene record: |
7804 |
| Pubmed identfication: |
8626535 9079678 |
| RefSeq identity: |
NM_004631 |
| Classification: |
Low density lipoprotein receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000008924 |