| Long name: |
ALEXA FLUOR 647 Conjugated, MRGPRX1/3/4 Polyclonal Antibody |
| Also known as: |
Anti-MRGPRX1/3/4 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MRGPRX1/3/4 |
| Specificity: |
This is a highly specific antibody against MRGPRX1/3/4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-35/322 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MRGX1 |
| Gene ID Number: |
117195, 117196, 259249 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells, G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors, G(alpha)q proteins are involved in the calcium-signaling pathway, MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons, MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, May regulate nociceptor function and/or development, Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22), Probably involved in the function of nociceptive neurons, including the sensation or modulation of pain, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways, There are four members (MRGX1-4) in the human MRGX familly |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
MRGX1 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the MRGPRX1/3/4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
MRGPRX1/3/4 |
| Short name: |
MRGPRX1/3/4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, member X1/3/4 (Antibody to), MAS-related GPR |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
G-protein coupled receptor activity, MRGPRX1 and IDBG-35377 and ENSG00000170255 and 259249, Plasma membranes, member X1, this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006953 and acute-phase response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0016021 and integral component of membrane and cellular component, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity, MAS-related GPR |
| Identity: |
17962 |
| Gene: |
MRGPRX1 |
More about : MRGPRX1 |
| Long gene name: |
MAS related GPR family member X1 |
| Synonyms gene name: |
MAS-related GPR, member X1 |
| Locus: |
11p15, 1 |
| Discovery year: |
2005-05-09 |
| Entrez gene record: |
259249 |
| Pubmed identfication: |
11551509 |
| RefSeq identity: |
NM_147199 |
| Classification: |
Class A orphans , G protein-coupled receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000162655 |