| Long name: |
ALEXA FLUOR 647 Conjugated, MUSK Polyclonal Antibody |
| Also known as: |
Anti-MUSK PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MUSK |
| Specificity: |
This is a highly specific antibody against MUSK |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
260-310/869 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MUSK |
| Gene ID Number: |
4593 |
| Swiss Prot: |
O15146 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May also play a role within the central nervous system by mediating cholinergic responses, May positively regulate Rho family GTPases through FNTA, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, Mediates the phosphorylation of FNTA which promotes prenylation, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, synaptic plasticity and memory formation (By similarity), the kinase of the complex, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, the synapse between the motor neuron and the skeletal muscle (PubMed:25537362), Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the MUSK Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
MUSK |
| Short name: |
MUSK Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, MUSK (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7525 |
| Gene: |
MUSK |
More about : MUSK |
| Long gene name: |
muscle associated receptor tyrosine kinase |
| Synonyms gene name: |
muscle, receptor tyrosine kinase , skeletal |
| Locus: |
9q31, 3 |
| Discovery year: |
1997-04-10 |
| GenBank acession: |
AF006464 |
| Entrez gene record: |
4593 |
| Pubmed identfication: |
7546737 |
| Classification: |
I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020485 |