| Long name: |
173, 44) Monoclonal Antibody, Musk (1429CT456 |
| Also known as: |
173, 44) Monoclonal Antibody, Musk (1429CT456 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Musk |
| Specificity: |
This is a highly specific antibody against Musk |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1429CT456, 44, 173 |
| Source: |
This mouse Musk antibody is generated from a mouse immunized with recombinant protein from mouse Musk |
| Gene ID number: |
18198 |
| Swiss Prot: |
Q61006 |
| Tested Applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:25), WB(1:1000) |
| Cross reactivity: |
Rat, Mouse |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May also play a role within the central nervous system by mediating cholinergic responses, May positively regulate Rho family GTPases through FNTA, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, Mediates the phosphorylation of FNTA which promotes prenylation, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, synaptic plasticity and memory formation, the kinase of the complex, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, the synapse between the motor neuron and the skeletal muscle, Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Mdk4, MuSK, Muscle, Muscle-specific kinase receptor, Muscle-specific tyrosine-protein kinase receptor, Nsk1, Nsk2, Nsk3, skeletal receptor tyrosine-protein kinase, Mlk |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
173, 44) Monoclonal, Musk (1429CT456 |
| Short name: |
173, 44) Monoclonal Antibody, Musk (1429CT456 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
173, 44) monoclonal (Antibody to), Musk (1429CT456 |
| Alternative technique: |
antibodies |