| Long name: |
Biotin Conjugated, UHRF1/2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UHRF1/2 |
| Specificity: |
This is a highly specific antibody against UHRF1/2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
720-770/793 |
| Subcellular location: |
Helical |
| Source: |
KLH conjugated synthetic peptide derived from human UHRF1 |
| Gene ID number: |
29128, 115426 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also ubiquitinates PCNP leading to its degradation by the proteasome, Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, CCND1 and CCNE1, E3 SUMO-, Important for G1/S transition, May be involved in DNA repair and chromosomal stability, May participate in methylation-dependent transcriptional regulation, Overexpressed in breast cancer, Through cooperative DNA and histone binding, UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network, Ubiquitinates cyclins, and activates TOP2A expression, bone marrow, but not ubiquitin-, in an apparently phosphorylation-independent manner and induces G1 arrest, lung and heart, may contribute to a tighter epigenetic control of gene expression in differentiated cells, protein ligase for ZNF131, testis, Putative E3 ubiquitin-protein ligase, Tissue specificity:Expressed in thymus |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
ICBP90 Np95 FLJ21925 RNF106 TDRD22 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UHRF1/2 Conjugated |
| Short name: |
Conjugated, UHRF1/2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, UHRF1/2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12556 |
| Gene: |
UHRF1 |
More about : UHRF1 |
| Long gene name: |
ubiquitin like with PHD and ring finger domains 1 |
| Locus: |
19p13, 3 |
| Discovery year: |
2000-03-15 |
| GenBank acession: |
AF129507 |
| Entrez gene record: |
29128 |
| Pubmed identfication: |
10646863 |
| RefSeq identity: |
NM_001048201 |
| Classification: |
PHD finger proteins Ring finger proteins Tudor domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000180251 |