| Long name: |
UHRF1/2 Primary Polyclonal Antibody |
| Also known as: |
UHRF1/2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
UHRF1/2 |
| Specificity: |
This is a highly specific antibody against UHRF1/2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
720-770/793 |
| Subcellular location: |
Helical |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UHRF1 |
| Gene ID number: |
29128, 115426 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also ubiquitinates PCNP leading to its degradation by the proteasome, Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, CCND1 and CCNE1, E3 SUMO-, Important for G1/S transition, May be involved in DNA repair and chromosomal stability, May participate in methylation-dependent transcriptional regulation, Overexpressed in breast cancer, Through cooperative DNA and histone binding, UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network, Ubiquitinates cyclins, and activates TOP2A expression, bone marrow, but not ubiquitin-, in an apparently phosphorylation-independent manner and induces G1 arrest, lung and heart, may contribute to a tighter epigenetic control of gene expression in differentiated cells, protein ligase for ZNF131, testis, Putative E3 ubiquitin-protein ligase, Tissue specificity:Expressed in thymus |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
1, 90-kD, 95-KD, E3 ubiquitin-protein ligase UHRF1, E3 ubiquitin-protein ligase UHRF2, ICBP90, Inverted CCAAT box binding protein, Inverted CCAAT box binding protein of 90 kDa, Inverted CCAAT box-binding protein of 90 kDa, Liver regeneration-related protein LRRG126, NP95, Nuclear phosphoprotein, Nuclear protein 95, Nuclear zinc finger protein Np95, RING finger protein 106, RNF106, Transcription factor ICBP90, UHRF1, UHRF1_HUMAN, UHRF2, UHRF2_HUMAN, Ubiquitin like PHD and RING finger domain containing protein 1, Ubiquitin like containing PHD and RING finger domains protein 1, Ubiquitin-like, Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like protein containing PHD and RING finger domains 1, Ubiquitin-like with PHD and ring finger domains 1, Ubiquitin-like-containing PHD and RING finger domains protein 1, Ubiquitin-like-containing PHD and RING finger domains protein 2, containing PHD and RING finger domains, HuNp95 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UHRF1/2 |
| Short name: |
UHRF1/2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
UHRF1/2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12556 |
| Gene: |
UHRF1 |
More about : UHRF1 |
| Long gene name: |
ubiquitin like with PHD and ring finger domains 1 |
| Synonyms: |
ICBP90 Np95 FLJ21925 RNF106 TDRD22 |
| Locus: |
19p13, 3 |
| Discovery year: |
2000-03-15 |
| GenBank acession: |
AF129507 |
| Entrez gene record: |
29128 |
| Pubmed identfication: |
10646863 |
| RefSeq identity: |
NM_001048201 |
| Classification: |
PHD finger proteins Ring finger proteins Tudor domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000180251 |