| Long name: |
ERK5 Primary Polyclonal Antibody |
| Also known as: |
ERK5 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ERK5 |
| Specificity: |
This is a highly specific antibody against ERK5 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
75-125/816 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ERK5/MAPK7 |
| Gene ID number: |
5598 |
| Swiss Prot: |
Q13164 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway, Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction, MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways, May be important for endothelial function and maintenance of blood vessel integrity, May have a role in muscle cell differentiation, Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression, The upstream activator of MAPK7 is the MAPK kinase MAP2K5, Upon activation, differentiation and cell survival, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C, Plays a role in various cellular processes such as proliferation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BMK-1, Big MAP kinase 1, ERK-5, ERK4, ERK5, Extracellular signal-regulated kinase 5, MAP kinase 7, MAPK 7, MAPK7, Mitogen-activated protein kinase 7, PRKM7, BMK1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ERK5 |
| Short name: |
ERK5 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ERK5 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6880 |
| Gene: |
MAPK7 |
More about : MAPK7 |
| Long gene name: |
mitogen-activated protein kinase 7 |
| Synonyms gene: |
PRKM7 |
| Synonyms: |
BMK1 ERK5 |
| Synonyms name: |
BMK1 kinase extracellular-signal-regulated kinase 5 |
| Locus: |
17p11, 2 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
U25278 |
| Entrez gene record: |
5598 |
| Pubmed identfication: |
10072598 7759517 |
| RefSeq identity: |
NM_139033 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000059587 |