| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ERK5 (MAPK7) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, IHC, WB |
| Recommended dilutions: |
IHC (Paraffin): 1:50-1:100, Western blot: 1:1000 |
| Notes: |
Titration of the ERK5 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ERK5 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q13164 |
| Purity: |
Purified |
| Description: |
ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, abundantly in heart, but is not detectable in liver, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways, is absent, kidney and skeletal muscle, lung, placenta, which could have a regulatory role, MEK5 and ERK5 |
| Immunogen: |
A portion of amino acids 776-805 from the human protein was used as the immunogen for this ERK5 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ERK5 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ERK5 (MAPK7) |
| Short name: |
ERK5 Antibody (MAPK7) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ERK5 (Antibody to) (mitogen-activated protein kinase 7) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BMK1 and ERK4 and ERK5 and PRKM7, MAPK7 and IDBG-34638 and ENSG00000166484 and 5598, MAPK7 and IDBG-637775 and ENSBTAG00000001014 and 537703, Mapk7 and IDBG-183076 and ENSMUSG00000001034 and 23939, alcohol group as acceptor, alcohol group as acceptor and also this GO :0051019 : mitogen-activated protein kinase binding, alcohol group as acceptor and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0019933 and cAMP-mediated signaling and biological process this GO :0030154 and cell differentiation and biological process this GO :0030821 and negative regulation of cAMP catabolic process and biological process this GO :0034115 and negative regulation of heterotypic cell-cell adhesion and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0036003 and positive regulation of transcription from RNA polymerase II promoter in response to stress and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0050728 and negative regulation of inflammatory response and biological process this GO :0051019 and mitogen-activated protein kinase binding and molecular function this GO :0051247 and positive regulation of protein metabolic process and biological process this GO :0051344 and negative regulation of cyclic-nucleotide phosphodiesterase activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0051534 and negative regulation of NFAT protein import into nucleus and biological process this GO :0060761 and negative regulation of response to cytokine stimulus and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071363 and cellular response to growth factor stimulus and biological process this GO :0071499 and cellular response to laminar fluid shear stress and biological process this GO :0071560 and cellular response to transforming growth factor beta stimulus and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process this GO :2000352 and negative regulation of endothelial cell apoptotic process and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, nuclei, this GO :0000165 and MAPK cascade and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004707 and MAP kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0007049 and cell cycle and biological process this GO :0007165 and signal transduction and biological process this GO :0008152 and metabolic process and biological process this GO :0009103 and lipopolysaccharide biosynthetic process and biological process this GO :0016020 and membrane and cellular component this GO :0016605 and PML body and cellular component this GO :0016772 and transferase activity, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004674 : protein serine/threonine kinase activity and also this GO :0004707 : MAP kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004674 : protein serine/threonine kinase activity, this GO :0004707 : MAP kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0016773 : phosphotransferase activity, this GO :0051019 : mitogen-activated protein kinase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773 : phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, mitogen-activated protein kinase 7 |
| Identity: |
6880 |
| Gene: |
MAPK7 |
More about : MAPK7 |
| Long gene name: |
mitogen-activated protein kinase 7 |
| Synonyms gene: |
PRKM7 |
| Synonyms: |
BMK1 ERK5 |
| Synonyms name: |
BMK1 kinase extracellular-signal-regulated kinase 5 |
| Locus: |
17p11, 2 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
U25278 |
| Entrez gene record: |
5598 |
| Pubmed identfication: |
10072598 7759517 |
| RefSeq identity: |
NM_139033 |
| Classification: |
Mitogen-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000059587 |