| Long name: |
Biotin Conjugated, NARC1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NARC1 |
| Specificity: |
This is a highly specific antibody against NARC1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
235-285/692 |
| Subcellular location: |
Lysosome, Secreted, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human PCSK9/NARC1 |
| Gene ID number: |
255738 |
| Swiss Prot: |
Q8NBP7 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway, Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation, Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner, Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751), May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation, PubMed:17461796, PubMed:18197702, PubMed:22074827), Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways, and promotes their degradation in intracellular acidic compartments (PubMed:18039658), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), very low density lipoprotein receptor (VLDLR), Crucial player in the regulation of plasma cholesterol homeostasis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
HCHOLA3, LDLCQ1, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, PSEC0052, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, FH3 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NARC1 Conjugated |
| Short name: |
Conjugated, NARC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, NARC1 (Antibody to) |
| Alternative technique: |
antibodies |