| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
NARC1 |
| Specificity: |
This antibody reacts specifically with NARC1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Lysosome, Secreted, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human PCSK9/NARC1 |
| Gene ID: |
255738 |
| Swiss Prot: |
Q8NBP7 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway, Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation, Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner, Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751), May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation, PubMed:17461796, PubMed:18197702, PubMed:22074827), Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways, and promotes their degradation in intracellular acidic compartments (PubMed:18039658), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), very low density lipoprotein receptor (VLDLR), Crucial player in the regulation of plasma cholesterol homeostasis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HCHOLA3, LDLCQ1, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, PSEC0052, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, FH3 |
| Also known as: |
NARC1 Polyclonal Antibody |
| Other name: |
Anti-NARC1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
NARC1 |
| Short name: |
Anti-NARC1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-NARC1 (polyclonal) |
| Alternative technique: |
polyclonals |