| Long name: |
TSLC1 Primary Polyclonal Antibody |
| Also known as: |
TSLC1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TSLC1 |
| Specificity: |
This is a highly specific antibody against TSLC1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
70-120/442 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CADM1/TSLC1 |
| Gene ID number: |
23705 |
| Swiss Prot: |
Q9BY67 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity), Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells, Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner, CADM1, In mast cells, Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo, May be involved in neuronal migration, May contribute to the less invasive phenotypes of lepidic growth tumor cells, May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa, and fasciculation on the axons of differentiating neurons, axon growth, is essential for development and survival of mast cells in vivo, may mediate attachment to and promote communication with nerves, pathfinding, together with MITF, Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CADM1, Cell adhesion molecule 1, IGSF4, IGSF4A, Immunoglobulin superfamily member 4, NECL2, Necl-2, Nectin-like protein 2, RA175, ST17, SYNCAM, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule, TSLC-1, TSLC1, Tumor suppressor in lung cancer 1, sTSLC-1, sgIGSF, synCAM1, BL2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TSLC1 |
| Short name: |
TSLC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TSLC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
5951 |
| Gene: |
CADM1 |
More about : CADM1 |
| Long gene name: |
cell adhesion molecule 1 |
| Synonyms gene: |
TSLC1 IGSF4 |
| Synonyms gene name: |
member 4 , tumor suppressor in lung cancer 1 immunoglobulin superfamily |
| Synonyms: |
NECL2 ST17 BL2 SYNCAM IGSF4A Necl-2 SYNCAM1 RA175 |
| Synonyms name: |
nectin-like 2 |
| Locus: |
11q23, 3 |
| Discovery year: |
1998-11-02 |
| GenBank acession: |
AB017563 |
| Entrez gene record: |
23705 |
| Pubmed identfication: |
10610705 |
| RefSeq identity: |
NM_014333 |
| Classification: |
C2-set domain containing Immunoglobulin like domain containing V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000168202 |