| Long name: |
FITC Conjugated, USP28 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
USP28 |
| Specificity: |
This is a highly specific antibody against USP28 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human USP28 |
| Gene ID number: |
57646 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also involved in G2 DNA damage checkpoint, In contrast, In contrast, Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN, Specifically deubiquitinates MYC in the nucleoplasm, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C), by deubiquitinating CLSPN, it does not deubiquitinate PLK1, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex, Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA1515 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
USP28 Conjugated |
| Short name: |
FITC Conjugated, USP28 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, ubiquitin specific peptidase 28 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, USP28 and IDBG-71844 and ENSG00000048028 and 57646, Usp28 and IDBG-162407 and ENSMUSG00000032267 and 235323, nuclei, this GO :0000077 and DNA damage checkpoint and biological process this GO :0004221 and ubiquitin thiolesterase activity and molecular function this GO :0004843 and ubiquitin-specific protease activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006281 and DNA repair and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0016579 and protein deubiquitination and biological process this GO :0034644 and cellular response to UV and biological process this GO :0036459 and ubiquitinyl hydrolase activity and molecular function this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043234 and protein complex and cellular component, this GO :0004221 : ubiquitin thiolesterase activity, this GO :0004221 : ubiquitin thiolesterase activity and also this GO :0004843 : ubiquitin-specific protease activity and also this GO :0005515 : protein binding and also this GO :0008234 : cysteine-type peptidase activity and also this GO :0036459 : ubiquitinyl hydrolase activity, this GO :0004843 : ubiquitin-specific protease activity, this GO :0005515 : protein binding, this GO :0008234 : cysteine-type peptidase activity, this GO :0036459 : ubiquitinyl hydrolase activity, ubiquitinyl hydrolase activity, 24505 and IDBG-630659 and ENSBTAG00000002323 and 508902, ubiquitin specific peptidase 28 |
| Identity: |
12625 |
| Gene: |
USP28 |
More about : USP28 |
| Long gene name: |
ubiquitin specific peptidase 28 |
| Synonyms gene name: |
ubiquitin specific protease 28 |
| Locus: |
11q23, 2 |
| Discovery year: |
2000-05-26 |
| GenBank acession: |
AB040948 |
| Entrez gene record: |
57646 |
| Pubmed identfication: |
12838346 11597335 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000168205 |