| Long name: |
USP28 Primary Polyclonal Antibody |
| Also known as: |
USP28 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
USP28 |
| Specificity: |
This is a highly specific antibody against USP28 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human USP28 |
| Gene ID number: |
57646 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also involved in G2 DNA damage checkpoint, In contrast, In contrast, Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN, Specifically deubiquitinates MYC in the nucleoplasm, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C), by deubiquitinating CLSPN, it does not deubiquitinate PLK1, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex, Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
KIAA1515, UBP28_HUMAN, USP 28, USP28, USP28 protein, Ubiquitin carboxyl terminal hydrolase 28, Ubiquitin carboxyl-terminal hydrolase 28, Ubiquitin specic peptidase 28, Ubiquitin specic processing protease 28, Ubiquitin specic protease 28, Ubiquitin thioesterase 28, Ubiquitin thiolesterase 28, Ubiquitin-specic-processing protease 28, Deubiquitinating enzyme 28 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
USP28 |
| Short name: |
USP28 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ubiquitin specific peptidase 28 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, USP28 and IDBG-71844 and ENSG00000048028 and 57646, Usp28 and IDBG-162407 and ENSMUSG00000032267 and 235323, nuclei, this GO :0000077 and DNA damage checkpoint and biological process this GO :0004221 and ubiquitin thiolesterase activity and molecular function this GO :0004843 and ubiquitin-specific protease activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0006281 and DNA repair and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0008283 and cell proliferation and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0016579 and protein deubiquitination and biological process this GO :0034644 and cellular response to UV and biological process this GO :0036459 and ubiquitinyl hydrolase activity and molecular function this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043234 and protein complex and cellular component, this GO :0004221 : ubiquitin thiolesterase activity, this GO :0004221 : ubiquitin thiolesterase activity and also this GO :0004843 : ubiquitin-specific protease activity and also this GO :0005515 : protein binding and also this GO :0008234 : cysteine-type peptidase activity and also this GO :0036459 : ubiquitinyl hydrolase activity, this GO :0004843 : ubiquitin-specific protease activity, this GO :0005515 : protein binding, this GO :0008234 : cysteine-type peptidase activity, this GO :0036459 : ubiquitinyl hydrolase activity, ubiquitinyl hydrolase activity, 24505 and IDBG-630659 and ENSBTAG00000002323 and 508902, ubiquitin specific peptidase 28 |
| Identity: |
12625 |
| Gene: |
USP28 |
More about : USP28 |
| Long gene name: |
ubiquitin specific peptidase 28 |
| Synonyms gene name: |
ubiquitin specific protease 28 |
| Synonyms: |
KIAA1515 |
| Locus: |
11q23, 2 |
| Discovery year: |
2000-05-26 |
| GenBank acession: |
AB040948 |
| Entrez gene record: |
57646 |
| Pubmed identfication: |
12838346 11597335 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000168205 |