Girdin Antibody

Catalog number:	bs-5150R Buy Now
Price:	368 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Girdin Antibody
Quantity:	0.1ml
Related search:	dna antibody gene activity synonyms cross

More details Need more?:

Long name:	Girdin Primary Polyclonal Antibody
Also known as:	Girdin PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	Girdin
Specificity:	This is a highly specific antibody against Girdin
Modification(s):	None
Modification site(s):	Unmodified antibody
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	1450-1500/1870
Subcellular location:	Cell membrane, Cytoplasm
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APE/Girdin
Gene ID number:	328
Swiss Prot:	P27695
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Rat, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB, Also involved in the DNA cleavage step of class switch recombination (CSR), Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER, Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs), May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation, On the other hand, Plays a role in the protection from granzymes-mediated cellular repair leading to cell death, Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks, The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors, and single-stranded RNA molecules, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends, single-stranded DNA regions of R-loop structures, such as the FOS/JUN AP-1 complex after exposure to IR, Multifunctional protein that plays a central role in the cellular response to oxidative stress
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	AP endonuclease 1, APE-1, APE1, APEN, APEX, APEX nuclease, APEX1, APX, Apurinic-apyrimidinic endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, HAP1, REF-1, REF1, Redox factor-1, APE
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	Girdin
Short name:	Girdin Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	Girdin (Antibody to)
Alternative technique:	antibodies
Identity:	25523
Gene:	CCDC88A | More about : CCDC88A
Long gene name:	coiled-coil domain containing 88A
Synonyms gene:	KIAA1212
Synonyms gene name:	KIAA1212
Synonyms:	FLJ10392 APE GIV HkRP1 GRDN
Synonyms name:	Galpha-interacting vesicle-associated protein Akt-phosphorylation enhancer girdin girders of actin filaments
Locus:	2p16, 1
Discovery year:	2004-01-13
GenBank acession:	AB033038 AF112218
Entrez gene record:	55704
Pubmed identfication:	15749703 15753085
RefSeq identity:	NM_017571
Havana BLAST/BLAT:	OTTHUMG00000151915

• #dna
• #antibody
• #gene
• #activity
• #synonyms
• #cross