| Long name: |
Biotin Conjugated, MAP 1A/1B LC3 A/B Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MAP 1A/1B LC3 Alpha/Beta |
| Specificity: |
This is a highly specific antibody against MAP 1A/1B LC3 Alpha/Beta |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
20-70/121 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human MAP LC3 Alpha |
| Gene ID number: |
54901, 84557 |
| Swiss Prot: |
Q9GZQ8, Q9H492 |
| Tested applications: |
IHC-P |
| Recommended dilutions: |
IHC-P(1:100-500) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
It is expressed primarily in heart, LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3â, LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3â, MAP LC3 Beta may also be involved in formation of autophagosomal vacuoles, MAP-LC3M Beta, MAP-light chain 3 beta (MAP-LC3 Beta) and MAP-light chain 3 alpha (MAP-LC3 alpha) are subunits of both MAP1A and MAP1B, This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation, Two forms of LC3 Beta, a homolog of Apg8p, are produced post-translationally, brain and skeletal muscle, followed by the conversion of a fraction of LC3-I into LC3-II, is essential for autophagy and associated to the autophagosome membranes after processing, testis, the cytosolic LC3-I and the membrane-bound LC3-II, untranslated region of fibronectin mRNA, &circ, &euro, «, &trade, Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
MAP1BLC3 MAP1ALC3 LC3 LC3A ATG8E |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MAP 1A/1B LC3 A/B Conjugated |
| Short name: |
Conjugated, MAP 1A/1B LC3 A/B Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, mitogen-stimulated protein kinase 1A/1B LC3 A/B (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6838 |
| Gene: |
MAP1LC3A |
More about : MAP1LC3A |
| Long gene name: |
microtubule associated protein 1 light chain 3 alpha |
| Locus: |
20q11, 22 |
| Discovery year: |
2000-06-29 |
| Entrez gene record: |
84557 |
| Pubmed identfication: |
8833088 17580304 |
| RefSeq identity: |
NM_181509 |
| Classification: |
Autophagy related |
| Havana BLAST/BLAT: |
OTTHUMG00000032306 |