| Long name: |
Cy5, 5 Conjugated, HAUSP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HAUSP |
| Specificity: |
This is a highly specific antibody against HAUSP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
850-900/1102 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human HAUSP/USP7 |
| Gene ID number: |
7874 |
| Swiss Prot: |
Q93009 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection, DNMT1, Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity, ERCC6, Exhibits a preference towards 'Lys-48'-linked ubiquitin chains, In association with DAXX, Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222), Involved in cell proliferation during early embryonic development, Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, MDM2, PTEN and DAXX, Together with DAXX, UHRF1, and also induces p53/TP53-dependent cell growth repression and apoptosis, both processes that are counteracted by PML, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, p53/TP53, preventing UV-induced degradation of ERCC6, preventing their degradation and promoting DNA methylation by DNMT1, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation, Hydrolase that deubiquitinates target proteins such as FOXO4 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
HAUSP Conjugated |
| Short name: |
Conjugated, HAUSP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, 5 coupled, HAUSP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12630 |
| Gene: |
USP7 |
More about : USP7 |
| Long gene name: |
ubiquitin specific peptidase 7 |
| Synonyms gene: |
HAUSP |
| Synonyms gene name: |
ubiquitin specific peptidase 7 (herpes virus-associated) |
| Locus: |
16p13, 2 |
| Discovery year: |
1998-10-12 |
| GenBank acession: |
Z72499 |
| Entrez gene record: |
7874 |
| Pubmed identfication: |
12838346 9925944 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000176903 |