| Long name: |
Biotin Conjugated, HAUSP Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
HAUSP |
| Specificity: |
This is a highly specific antibody against HAUSP |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
850-900/1102 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human HAUSP/USP7 |
| Gene ID number: |
7874 |
| Swiss Prot: |
Q93009 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection, DNMT1, Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity, ERCC6, Exhibits a preference towards 'Lys-48'-linked ubiquitin chains, In association with DAXX, Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function (PubMed:23973222), Involved in cell proliferation during early embryonic development, Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, MDM2, PTEN and DAXX, Together with DAXX, UHRF1, and also induces p53/TP53-dependent cell growth repression and apoptosis, both processes that are counteracted by PML, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, p53/TP53, preventing UV-induced degradation of ERCC6, preventing their degradation and promoting DNA methylation by DNMT1, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation, Hydrolase that deubiquitinates target proteins such as FOXO4 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HAUSP Conjugated |
| Short name: |
Conjugated, HAUSP Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, HAUSP (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12630 |
| Gene: |
USP7 |
More about : USP7 |
| Long gene name: |
ubiquitin specific peptidase 7 |
| Synonyms gene: |
HAUSP |
| Synonyms gene name: |
ubiquitin specific peptidase 7 (herpes virus-associated) |
| Locus: |
16p13, 2 |
| Discovery year: |
1998-10-12 |
| GenBank acession: |
Z72499 |
| Entrez gene record: |
7874 |
| Pubmed identfication: |
12838346 9925944 |
| Classification: |
Ubiquitin specific peptidases |
| Havana BLAST/BLAT: |
OTTHUMG00000176903 |