Cullin 3 Antibody, ALEXA FLUOR 594

Catalog number:	bs-4211R-A594 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	Cullin 3 Antibody, ALEXA FLUOR 594
Quantity:	100ul
Related search:	cullin antibody ubiquitination pubmed complex the cullinringbased

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Long name:	ALEXA FLUOR 594 Conjugated, Cullin 3 Polyclonal Antibody
Also known as:	Anti-Cullin 3 PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Cullin 3
Specificity:	This is a highly specific antibody against Cullin 3
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	430-480/768
Subcellular location:	Nucleus
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Cullin 3
Gene ID Number:	8452
Swiss Prot:	Q13618
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, BCR(KLHL42) is involved in ubiquitination of KATNA1, BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis, BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, GLI2 and GLI3, H2AFY and DAXX, PubMed:21670212, PubMed:21840486, PubMed:24768539), The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity), The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component, by mediating ubiquitination of WNK4, thereby playing a key role in collagen export, these complexes have lower ubiquitin ligase activity, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B), Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	Cullin 3
Short name:	Cullin 3 Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, Cullin 3 (Antibody to)
Alternative technique:	antibodies
Identity:	2553
Gene:	CUL3 | More about : CUL3
Long gene name:	cullin 3
Locus:	2q36, 2
Discovery year:	1998-10-29
GenBank acession:	U58089
Entrez gene record:	8452
Pubmed identfication:	8681378 17192413
Classification:	Cullins
Havana BLAST/BLAT:	OTTHUMG00000133167

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