| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Cullin 7 |
| Specificity: |
This antibody reacts specifically with Cullin 7 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Cullin 7 |
| Gene ID: |
9820 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, In vitro, Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity), Seems not to promote polyubiquitination and proteasomal degradation of TP53, Skeletal changes include long slender tubular bones and tall vertebral bodies, and normal intelligence and endocrine function, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity, facial dysmorphism, large head circumference, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, Component of a probable SCF-like E3 ubiquitin-protein ligase complex, Involvement in disease: Defects in CUL7 are the cause of 3M syndrome type 1 (3M1) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
dJ20C7, 5 |
| Also known as: |
Cullin 7 Polyclonal Antibody |
| Other name: |
Anti-Cullin 7 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Cullin 7 |
| Short name: |
Anti-Cullin 7 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Cullin 7 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
21024 |
| Gene: |
CUL7 |
More about : CUL7 |
| Long gene name: |
cullin 7 |
| Synonyms gene: |
KIAA0076 |
| Synonyms gene name: |
KIAA0076 |
| Locus: |
6p21, 1 |
| Discovery year: |
2003-11-21 |
| GenBank acession: |
BC033647 |
| Entrez gene record: |
9820 |
| Pubmed identfication: |
12481031 12904573 |
| RefSeq identity: |
NM_014780 |
| Classification: |
Cullins |
| Havana BLAST/BLAT: |
OTTHUMG00000014718 |