| Long name: |
Adenomatous Polyposis Coli Antibody |
| Also known as: |
Adenomatous Polyposis Coli Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
APC/Adenomatous Polyposis Coli |
| Specificity: |
This is a highly specific antibody against APC/Adenomatous Polyposis Coli |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
2790-2843/2843 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APC |
| Gene ID number: |
324 |
| Swiss Prot: |
P25054 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
APC activity is correlated with its phosphorylation state, Activates the GEF activity of SPATA13 and ARHGEF4, Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex, It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization, Plays a role in hepatocyte growth factor (HGF)-induced cell migration, Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator, Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells, Tumor suppressor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
APC, Adenomatous polyposis coli protein, BTPS2, DP2, DP2, DP3, Deleted in polyposis 2, PPP1R46, Protein APC, 5, 5, GS |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Adenomatous Polyposis Coli |
| Short name: |
Adenomatous Polyposis Coli Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Adenomatous Polyposis Coli (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
24036 |
| Gene: |
APC2 |
More about : APC2 |
| Long gene name: |
APC2, WNT signaling pathway regulator |
| Synonyms gene name: |
adenomatosis polyposis coli 2 |
| Synonyms: |
APCL |
| Synonyms name: |
adenomatous polyposis coli like |
| Locus: |
19p13, 3 |
| Discovery year: |
2004-03-18 |
| Entrez gene record: |
10297 |
| Pubmed identfication: |
9823329 10021369 |
| RefSeq identity: |
NM_005883 |
| Classification: |
Armadillo repeat containing |
| Havana BLAST/BLAT: |
OTTHUMG00000180059 |