| Long name: |
ALEXA FLUOR 488 Conjugated, ADAM10 Polyclonal Antibody |
| Also known as: |
Anti-ADAM10 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ADAM10 |
| Specificity: |
This is a highly specific antibody against ADAM10 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
623-672/748 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ADAM10 |
| Gene ID Number: |
102 |
| Swiss Prot: |
O14672 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B, Contributes to the normal cleavage of the cellular prion protein, Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis, Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, May regulate the EFNA5-EPHA3 signaling, Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form, Responsible for the proteolytic release of several other cell-surface proteins, Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP), including heparin-binding epidermal growth-like factor, suggesting a vesicle-based protease activity, Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
kuz MADM HsT18717 CD156c |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the ADAM10 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
ADAM10 |
| Short name: |
ADAM10 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, ADAM metallopeptidase domain 10 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AD10 and AD18 and CD156c and HsT18717 and kuz and MADM and RAK, ADAM10 and IDBG-14155 and ENSG00000137845 and 102, ADAM10 and IDBG-646594 and ENSBTAG00000005481 and 282132, Adam10 and IDBG-182594 and ENSMUSG00000054693 and 11487, nuclei, protein homodimerization activity, this GO :0001701 and in utero embryonic development and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005798 and this GO lgi-associated vesicle and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008219 and cell death and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0042117 and monocyte activation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045087 and innate immune response and biological process this GO :0051088 and PMA-inducible membrane protein ectodomain proteolysis and biological process this GO :0051089 and constitutive protein ectodomain proteolysis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097038 and perinuclear endoplasmic reticulum and cellular component this GO :0097197 and tetraspanin-enriched microdomain and cellular component, this GO :0004175 : endopeptidase activity, this GO :0004175 : endopeptidase activity and also this GO :0004222 : metalloendopeptidase activity and also this GO :0005102 : receptor binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0008237 : metallopeptidase activity and also this GO :0008270 : zinc ion binding and also this GO :0017124 : SH3 domain binding and also this GO :0019901 : protein kinase binding and also this GO :0042803 : protein homodimerization activity, this GO :0004222 : metalloendopeptidase activity, this GO :0005102 : receptor binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0008237 : metallopeptidase activity, this GO :0008270 : zinc ion binding, this GO :0017124 : SH3 domain binding, this GO :0019901 : protein kinase binding, this GO :0042803 : protein homodimerization activity, ADAM metallopeptidase domain 10 |
| Identity: |
188 |
| Gene: |
ADAM10 |
More about : ADAM10 |
| Long gene name: |
ADAM metallopeptidase domain 10 |
| Synonyms gene name: |
a disintegrin and metalloproteinase domain 10 |
| Locus: |
15q21, 3 |
| Discovery year: |
1997-03-21 |
| GenBank acession: |
AF009615 |
| Entrez gene record: |
102 |
| Pubmed identfication: |
9344679 9441766 |
| RefSeq identity: |
NM_001110 |
| Classification: |
ADAM metallopeptidase domain containing CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000132633 |