| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
ADAM10 |
| Specificity: |
This antibody reacts specifically with ADAM10 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human ADAM10 |
| Gene ID: |
102 |
| Swiss Prot: |
O14672 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B, Contributes to the normal cleavage of the cellular prion protein, Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis, Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, May regulate the EFNA5-EPHA3 signaling, Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form, Responsible for the proteolytic release of several other cell-surface proteins, Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP), including heparin-binding epidermal growth-like factor, suggesting a vesicle-based protease activity, Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
kuz MADM HsT18717 CD156c |
| Also known as: |
ADAM10 Polyclonal Antibody |
| Other name: |
Anti-ADAM10 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
ADAM10 |
| Short name: |
Anti-ADAM10 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-ADAM metallopeptidase domain 10 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
AD10 and AD18 and CD156c and HsT18717 and kuz and MADM and RAK, ADAM10 and IDBG-14155 and ENSG00000137845 and 102, ADAM10 and IDBG-646594 and ENSBTAG00000005481 and 282132, Adam10 and IDBG-182594 and ENSMUSG00000054693 and 11487, nuclei, protein homodimerization activity, this GO :0001701 and in utero embryonic development and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004222 and metalloendopeptidase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005798 and this GO lgi-associated vesicle and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006508 and proteolysis and biological process this GO :0006509 and membrane protein ectodomain proteolysis and biological process this GO :0007162 and negative regulation of cell adhesion and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0007220 and Notch receptor processing and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0008219 and cell death and biological process this GO :0008237 and metallopeptidase activity and molecular function this GO :0008270 and zinc ion binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009986 and cell surface and cellular component this GO :0010820 and positive regulation of T cell chemotaxis and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0017124 and SH3 domain binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0022617 and extracellular matrix disassembly and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030307 and positive regulation of cell growth and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0030574 and collagen catabolic process and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0042117 and monocyte activation and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0045087 and innate immune response and biological process this GO :0051088 and PMA-inducible membrane protein ectodomain proteolysis and biological process this GO :0051089 and constitutive protein ectodomain proteolysis and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0097038 and perinuclear endoplasmic reticulum and cellular component this GO :0097197 and tetraspanin-enriched microdomain and cellular component, this GO :0004175 : endopeptidase activity, this GO :0004175 : endopeptidase activity and also this GO :0004222 : metalloendopeptidase activity and also this GO :0005102 : receptor binding and also this GO :0005178 : integrin binding and also this GO :0005515 : protein binding and also this GO :0008237 : metallopeptidase activity and also this GO :0008270 : zinc ion binding and also this GO :0017124 : SH3 domain binding and also this GO :0019901 : protein kinase binding and also this GO :0042803 : protein homodimerization activity, this GO :0004222 : metalloendopeptidase activity, this GO :0005102 : receptor binding, this GO :0005178 : integrin binding, this GO :0005515 : protein binding, this GO :0008237 : metallopeptidase activity, this GO :0008270 : zinc ion binding, this GO :0017124 : SH3 domain binding, this GO :0019901 : protein kinase binding, this GO :0042803 : protein homodimerization activity, ADAM metallopeptidase domain 10 |
| Identity: |
188 |
| Gene: |
ADAM10 |
More about : ADAM10 |
| Long gene name: |
ADAM metallopeptidase domain 10 |
| Synonyms gene name: |
a disintegrin and metalloproteinase domain 10 |
| Locus: |
15q21, 3 |
| Discovery year: |
1997-03-21 |
| GenBank acession: |
AF009615 |
| Entrez gene record: |
102 |
| Pubmed identfication: |
9344679 9441766 |
| RefSeq identity: |
NM_001110 |
| Classification: |
ADAM metallopeptidase domain containing CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000132633 |