| Long name: |
ALEXA FLUOR 488 Conjugated, Raptor Polyclonal Antibody |
| Also known as: |
Anti-Raptor PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Raptor |
| Specificity: |
This is a highly specific antibody against Raptor |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
100-150/1335 |
| Subcellular location: |
Lysosome, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Raptor |
| Gene ID Number: |
57521 |
| Swiss Prot: |
Q8N122 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis, Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases, Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, Involved in ciliogenesis, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates, mTORC1 is activated in response to growth factors or amino acids, mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E), mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation, Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
KOG1 Mip1 KIAA1303 raptor |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Raptor Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Raptor |
| Short name: |
Raptor Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Raptor (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30287 |
| Gene: |
RPTOR |
More about : RPTOR |
| Long gene name: |
regulatory associated protein of MTOR complex 1 |
| Synonyms gene name: |
complex 1 , regulatory associated protein of MTOR |
| Synonyms name: |
regulatory associated protein of mTOR |
| Locus: |
17q25, 3 |
| Discovery year: |
2009-05-29 |
| Entrez gene record: |
57521 |
| Pubmed identfication: |
10718198 12150926 |
| RefSeq identity: |
NM_020761 |
| Classification: |
MTOR complex 1 WD repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000177622 |