TrkA (Tyr496) Antibody, Cy5.5 Conjugated

Catalog number:	bs-3456R-Cy5.5 Buy Now
Price:	2277 €
Supplier:	MBS Recombinant Proteins
Product name:	TrkA (Tyr496) Antibody, Cy5.5 Conjugated
Quantity:	1000ug
Related search:	antibody trka antibodies survival kinase tyrosine cell high

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Long name:	Cy5, 5 Conjugated, TrkA (Tyr496) Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Cy5, 5, 5, Cy5
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	TrkA (Tyr496)
Specificity:	This antibody will recognize TrkB when phosphorylated at Tyr516 and TrkC when phosphorylated at Tyr516, This is a highly specific antibody against TrkA (Tyr496)
Modification:	Phosphorylation
Modification site:	Tyr496
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	480-520/796
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human TrkA around the phosphorylation site of Tyr496
Gene ID number:	4914
Swiss Prot:	P04629
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, FRS2, High affinity receptor for NGF which is its primary ligand, However, In absence of ligand and activation, Isoform TrkA-III is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Recruits, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, Upon dimeric NGF ligand-binding, autophosphorylation and activation, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, differentiation and survival of sympathetic and nervous neurons, it can also bind and be activated by NTF3/neurotrophin-3, making the survival of neurons dependent on trophic factors, may promote cell death, phosphorylates and/or activates several downstream effectors including SHC1, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission:	675nm/694nm
Synonyms:	MTC, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, TRKA, Trk-A, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, p140-TrkA, High affinity nerve growth factor receptor
Properties:	Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Conjugated:	These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene target:	TrkA (Tyr496) Conjugated
Short name:	Conjugated, TrkA (Tyr496) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	5, Cy5
Alternative name:	cyanine 5, 5 coupled, TrkA (Tyr496) (Antibody to)
Alternative technique:	antibodies

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