TrkA (Tyr496) Antibody

Catalog number:	bs-3456R Buy Now
Price:	2277 €
Supplier:	MBS Recombinant Proteins
Product name:	TrkA (Tyr496) Antibody
Quantity:	1000ug
Related search:	tyr antibody survival kinase tyrosine cell

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Long name:	TrkA (Tyr496) Primary Polyclonal Antibody
Also known as:	TrkA (Tyr496) PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	TrkA (Tyr496)
Specificity:	This antibody will recognize TrkB when phosphorylated at Tyr516 and TrkC when phosphorylated at Tyr516, This is a highly specific antibody against TrkA (Tyr496)
Modification(s):	Phosphorylation
Modification site(s):	Tyr496
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	480-520/796
Subcellular location:	Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human TrkA around the phosphorylation site of Tyr496
Gene ID number:	4914
Swiss Prot:	P04629
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Mouse, Human
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation, FRS2, High affinity receptor for NGF which is its primary ligand, However, In absence of ligand and activation, Isoform TrkA-III is resistant to NGF, Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival, Recruits, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation, Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival, Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival, Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival, Upon dimeric NGF ligand-binding, autophosphorylation and activation, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade, differentiation and survival of sympathetic and nervous neurons, it can also bind and be activated by NTF3/neurotrophin-3, making the survival of neurons dependent on trophic factors, may promote cell death, phosphorylates and/or activates several downstream effectors including SHC1, undergoes homodimerization, Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	MTC, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, TRKA, Trk-A, Tropomyosin-related kinase A, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, p140-TrkA, High affinity nerve growth factor receptor
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	TrkA (Tyr496)
Short name:	TrkA (Tyr496) Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	TrkA (Tyr496) (Antibody to)
Alternative technique:	antibodies

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