| Long name: |
ALEXA FLUOR 555 Conjugated, BAP1 (Ser592) Polyclonal Antibody |
| Also known as: |
Anti-BAP1 Ser592 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
BAP1 Ser592 |
| Specificity: |
This is a highly specific antibody against BAP1 Ser592 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser592 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
570-620/729 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592 |
| Gene ID Number: |
8314 |
| Swiss Prot: |
Q92560 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, Acts as a tumor suppressor, Catalytic component of the PR-DUB complex, Deubiquitination of HCFC1 does not lead to increase stability of HCFC1, Does not deubiquitinate monoubiquitinated histone H2B, Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination, It however does not mediate deubiquitination of BRCA1 and BARD1, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1), thereby protecting it from cytoplasmic sequestration (PubMed:24703950), with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains, Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
hucep-6 KIAA0272 UCHL2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
BAP1 (Ser592) |
| Short name: |
BAP1 (Ser592) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, BAP1 (Ser592) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
950 |
| Gene: |
BAP1 |
More about : BAP1 |
| Long gene name: |
BRCA1 associated protein 1 |
| Synonyms gene name: |
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) |
| Synonyms name: |
ubiquitin carboxy-terminal hydrolase |
| Locus: |
3p21, 1 |
| Discovery year: |
1998-09-17 |
| GenBank acession: |
AF045581 |
| Entrez gene record: |
8314 |
| Pubmed identfication: |
9528852 |
| Classification: |
Ubiquitin C-terminal hydrolases |
| Havana BLAST/BLAT: |
OTTHUMG00000158392 |
| Locus Specific Databases: |
LRG_529 |