| Long name: |
Cy5 Conjugated, BAP1 (Ser592) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
BAP1 Ser592 |
| Specificity: |
This phosphorylation site is homologous to the Ser590 site in Rat, This is a highly specific antibody against BAP1 Ser592 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser592 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
570-620/729 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BAP1 around the phosphorylation site of Ser592 |
| Gene ID number: |
8314 |
| Swiss Prot: |
Q92560 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, Acts as a tumor suppressor, Catalytic component of the PR-DUB complex, Deubiquitination of HCFC1 does not lead to increase stability of HCFC1, Does not deubiquitinate monoubiquitinated histone H2B, Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination, It however does not mediate deubiquitination of BRCA1 and BARD1, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1), thereby protecting it from cytoplasmic sequestration (PubMed:24703950), with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains, Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
625, 650nm/670nm |
| Synonyms: |
hucep-6 KIAA0272 UCHL2 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
BAP1 (Ser592) Conjugated |
| Short name: |
Conjugated, BAP1 (Ser592) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy5 |
| Alternative name: |
cyanine 5 coupled, BAP1 (Ser592) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
950 |
| Gene: |
BAP1 |
More about : BAP1 |
| Long gene name: |
BRCA1 associated protein 1 |
| Synonyms gene name: |
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) |
| Synonyms name: |
ubiquitin carboxy-terminal hydrolase |
| Locus: |
3p21, 1 |
| Discovery year: |
1998-09-17 |
| GenBank acession: |
AF045581 |
| Entrez gene record: |
8314 |
| Pubmed identfication: |
9528852 |
| Classification: |
Ubiquitin C-terminal hydrolases |
| Havana BLAST/BLAT: |
OTTHUMG00000158392 |
| Locus Specific Databases: |
LRG_529 |