| Long name: |
ASK1 (Thr845) Primary Polyclonal Antibody |
| Also known as: |
ASK1 (Thr845) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ASK1 Thr845 |
| Specificity: |
This is a highly specific antibody against ASK1 Thr845 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr845 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
825-875/1380 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from mouse ASK1 around the phosphorylation site of Thr845 |
| Gene ID number: |
26408 |
| Swiss Prot: |
O35099 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1), MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7, MAP3K5/ASK1 is required for the innate immune response, Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, Mediates signaling for determination of cell fate such as differentiation and survival, Once activated, Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation, Plays an important role in the cascades of cellular responses evoked by changes in the environment, These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs), acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS), which is essential for host defense against a wide range of pathogens, Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
742452D2Rik, ASK-1, ASK1, Apoptosis signal-regulating kinase 1, MAPK/ERK kinase kinase 5, MAPKKK5, MEK kinase 5, MEKK 5, Map3k5, Mekk5, Mitogen-activated protein kinase kinase kinase 5, ASK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ASK1 (Thr845) |
| Short name: |
ASK1 (Thr845) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ASK1 (Thr845) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6857 |
| Gene: |
MAP3K5 |
More about : MAP3K5 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 5 |
| Synonyms gene: |
MEKK5 |
| Synonyms: |
MAPKKK5 ASK1 |
| Synonyms name: |
apoptosis signal regulating kinase 1 |
| Locus: |
6q23, 3 |
| Discovery year: |
1997-11-14 |
| GenBank acession: |
U67156 |
| Entrez gene record: |
4217 |
| Pubmed identfication: |
9465908 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000015647 |
| Locus Specific Databases: |
The Globin Gene Server |