| Long name: |
ALEXA FLUOR 594 Conjugated, Mitofusin 2 Polyclonal Antibody |
| Also known as: |
Anti-Mitofusin 2 PAb ALEXA FLUOR 594 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Mitofusin 2 |
| Specificity: |
This is a highly specific antibody against Mitofusin 2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-50/757 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mitofusin 2 |
| Gene ID Number: |
9927 |
| Swiss Prot: |
O95140 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions, Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy), Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress, Is required for PARK2 recruitment to dysfunctional mitochondria, It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes, MFN2 acts independently of the cytoskeleton, Overexpression induces the formation of mitochondrial networks, Plays an important role in the regulation of vascular smooth muscle cell proliferation, which is balanced between fusion and fission, which mediates mitochondrial fusion, Essential transmembrane GTPase |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CPRP1 KIAA0214 MARF CMT2A2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
594, ALEXA FLUOR®, Alexa Fluor |
| Conjugated: |
Alexa conjugate 1 |
| Gene target: |
Mitofusin 2 |
| Short name: |
Mitofusin 2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 594 |
| Alternative name: |
ALEXA FLUOR 594, Mitofusin 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16877 |
| Gene: |
MFN2 |
More about : MFN2 |
| Long gene name: |
mitofusin 2 |
| Locus: |
1p36, 22 |
| Discovery year: |
2003-02-25 |
| GenBank acession: |
AF036536 |
| Entrez gene record: |
9927 |
| Pubmed identfication: |
12499352 11181170 |
| RefSeq identity: |
NM_014874 |
| Havana BLAST/BLAT: |
OTTHUMG00000002392 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_255 |