| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Mitofusin 2 |
| Specificity: |
This antibody reacts specifically with Mitofusin 2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Mitofusin 2 |
| Gene ID: |
9927 |
| Swiss Prot: |
O95140 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions, Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy), Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress, Is required for PARK2 recruitment to dysfunctional mitochondria, It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes, MFN2 acts independently of the cytoskeleton, Overexpression induces the formation of mitochondrial networks, Plays an important role in the regulation of vascular smooth muscle cell proliferation, which is balanced between fusion and fission, which mediates mitochondrial fusion, Essential transmembrane GTPase |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CPRP1 KIAA0214 MARF CMT2A2 |
| Also known as: |
Mitofusin 2 Polyclonal Antibody |
| Other name: |
Anti-Mitofusin 2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Mitofusin 2 |
| Short name: |
Anti-Mitofusin 2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Mitofusin 2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
16877 |
| Gene: |
MFN2 |
More about : MFN2 |
| Long gene name: |
mitofusin 2 |
| Locus: |
1p36, 22 |
| Discovery year: |
2003-02-25 |
| GenBank acession: |
AF036536 |
| Entrez gene record: |
9927 |
| Pubmed identfication: |
12499352 11181170 |
| RefSeq identity: |
NM_014874 |
| Havana BLAST/BLAT: |
OTTHUMG00000002392 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_255 |