| Long name: |
ALEXA FLUOR 488 Conjugated, PHGDH Polyclonal Antibody |
| Also known as: |
Anti-PHGDH PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PHGDH |
| Specificity: |
This is a highly specific antibody against PHGDH |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
120-160/533 |
| Subcellular location: |
Intracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PHGDH |
| Gene ID Number: |
26227 |
| Swiss Prot: |
O43175 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
3PGDH is regulated at the transcriptional level depending on tissue specificity and cellular proliferative status (2), 3PGDH protein is 544 amino acids in length, 3PGDH protein is also highly expressed in adult and fetal brain tissues (3), 3PGDH protein plays an important role in the metabolism, The trophic actions of glial cells on Purkinje neurons are mediated by L-serine and glycine, Two distinct mRNA transcripts that encode for 3PGDH protein in normal human tissues are dominant 2, and 710 bp mRNA, and function of the central nervous system (3) and its deficiency is a treatable congential error (4-5) that impairs L-serine biosynthesis which is characterized by congenital microcephaly, and heart, and pancreas, and seizures (3), and weakly expressed in thymus, brain, colon, development, kidney, liver, ovary, psychomotor retardation, testis, which are glia-derived trophic factors synthesized by 3PGDH (1), which is highly expressed in heart and skeletal muscle (2), which is highly expressed in prostate, 1 kb mRNA, The survival and development of central neurons require the supply of trophic factors by glial cells |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
SERA PGDH PDG |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the PHGDH Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
PHGDH |
| Short name: |
PHGDH Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, PHGDH (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8923 |
| Gene: |
PHGDH |
More about : PHGDH |
| Long gene name: |
phosphoglycerate dehydrogenase |
| Locus: |
1p12 |
| Discovery year: |
1999-11-22 |
| GenBank acession: |
BC011262 |
| Entrez gene record: |
26227 |
| RefSeq identity: |
NM_006623 |
| Havana BLAST/BLAT: |
OTTHUMG00000012100 |