| Long name: |
PHGDH Primary Polyclonal Antibody |
| Also known as: |
PHGDH PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PHGDH |
| Specificity: |
This is a highly specific antibody against PHGDH |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
120-160/533 |
| Subcellular location: |
Intracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PHGDH |
| Gene ID number: |
26227 |
| Swiss Prot: |
O43175 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
3PGDH is regulated at the transcriptional level depending on tissue specificity and cellular proliferative status (2), 3PGDH protein is 544 amino acids in length, 3PGDH protein is also highly expressed in adult and fetal brain tissues (3), 3PGDH protein plays an important role in the metabolism, The trophic actions of glial cells on Purkinje neurons are mediated by L-serine and glycine, Two distinct mRNA transcripts that encode for 3PGDH protein in normal human tissues are dominant 2, and 710 bp mRNA, and function of the central nervous system (3) and its deficiency is a treatable congential error (4-5) that impairs L-serine biosynthesis which is characterized by congenital microcephaly, and heart, and pancreas, and seizures (3), and weakly expressed in thymus, brain, colon, development, kidney, liver, ovary, psychomotor retardation, testis, which are glia-derived trophic factors synthesized by 3PGDH (1), which is highly expressed in heart and skeletal muscle (2), which is highly expressed in prostate, 1 kb mRNA, The survival and development of central neurons require the supply of trophic factors by glial cells |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
3-PGDH, 3PGDH, D-3-phosphoglycerate dehydrogenase, HEL-S-113, NLS1, PDG, PGAD, PGD, PGDH, PGDH3, PHGDH, PHGDHD, SERA, NLS |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PHGDH |
| Short name: |
PHGDH Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PHGDH (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8923 |
| Gene: |
PHGDH |
More about : PHGDH |
| Long gene name: |
phosphoglycerate dehydrogenase |
| Synonyms: |
SERA PGDH PDG |
| Locus: |
1p12 |
| Discovery year: |
1999-11-22 |
| GenBank acession: |
BC011262 |
| Entrez gene record: |
26227 |
| RefSeq identity: |
NM_006623 |
| Havana BLAST/BLAT: |
OTTHUMG00000012100 |