| Long name: |
ALEXA FLUOR 647 Conjugated, Tap1 Polyclonal Antibody |
| Also known as: |
Anti-Tap1 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Tap1 |
| Specificity: |
This is a highly specific antibody against Tap1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
525-575/808 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tap1/ABCB2 |
| Gene ID Number: |
6890 |
| Swiss Prot: |
Q03518 |
| Tested applications: |
IF(ICC), IF(IHC-P), FCM |
| Recommended dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also acts as a molecular scaffold for the final stage of MHC class I folding, Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-1 protein, Inhibited by human adenovirus E3-19K glycoprotein, Inhibited by human cytomegalovirus US6 glycoprotein, Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, Nascent MHC class I molecules associate with TAP via tapasin, namely the binding of peptide, preventing MHC class I/TAP association, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules, which binds the TAP complex and acts as a tapasin inhibitor, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding, which blocks the peptide-binding site of TAP, Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
XXbac-BPG246D15, 8 TAP1-AS1 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Tap1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
Tap1 |
| Short name: |
Tap1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, adenosine triphosphate-binding cassette, sub-family B (multi-drug-resistant/TAP) (Antibody to), transporter 1 |
| Alternative technique: |
antibodies |
| Identity: |
39758 |
| Gene: |
PSMB8-AS1 |
More about : PSMB8-AS1 |
| Long gene name: |
PSMB8 antisense RNA 1 (head to head) |
| Synonyms gene: |
TAPSAR1 |
| Synonyms gene name: |
TAP1 and PSMB8 antisense RNA 1 |
| Locus: |
6p21, 32 |
| Discovery year: |
2013-07-25 |
| Entrez gene record: |
100507463 |
| RefSeq identity: |
NR_037173 |
| Havana BLAST/BLAT: |
OTTHUMG00000140123 |