| Long name: |
ALEXA FLUOR 555 Conjugated, Tap1 Polyclonal Antibody |
| Also known as: |
Anti-Tap1 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Tap1 |
| Specificity: |
This is a highly specific antibody against Tap1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
525-575/808 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tap1/ABCB2 |
| Gene ID Number: |
6890 |
| Swiss Prot: |
Q03518 |
| Tested applications: |
IF(ICC), IF(IHC-P), FCM |
| Recommended dilutions: |
IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also acts as a molecular scaffold for the final stage of MHC class I folding, Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-1 protein, Inhibited by human adenovirus E3-19K glycoprotein, Inhibited by human cytomegalovirus US6 glycoprotein, Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, Nascent MHC class I molecules associate with TAP via tapasin, namely the binding of peptide, preventing MHC class I/TAP association, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules, which binds the TAP complex and acts as a tapasin inhibitor, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding, which blocks the peptide-binding site of TAP, Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
XXbac-BPG246D15, 8 TAP1-AS1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
Tap1 |
| Short name: |
Tap1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, adenosine triphosphate-binding cassette, sub-family B (multi-drug-resistant/TAP) (Antibody to), transporter 1 |
| Alternative technique: |
antibodies |
| Identity: |
39758 |
| Gene: |
PSMB8-AS1 |
More about : PSMB8-AS1 |
| Long gene name: |
PSMB8 antisense RNA 1 (head to head) |
| Synonyms gene: |
TAPSAR1 |
| Synonyms gene name: |
TAP1 and PSMB8 antisense RNA 1 |
| Locus: |
6p21, 32 |
| Discovery year: |
2013-07-25 |
| Entrez gene record: |
100507463 |
| RefSeq identity: |
NR_037173 |
| Havana BLAST/BLAT: |
OTTHUMG00000140123 |