| Long name: |
Tap1 Primary Polyclonal Antibody |
| Also known as: |
Tap1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Tap1 |
| Specificity: |
This is a highly specific antibody against Tap1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
525-575/808 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Tap1/ABCB2 |
| Gene ID number: |
6890 |
| Swiss Prot: |
Q03518 |
| Tested Applications: |
FCM, IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also acts as a molecular scaffold for the final stage of MHC class I folding, Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-1 protein, Inhibited by human adenovirus E3-19K glycoprotein, Inhibited by human cytomegalovirus US6 glycoprotein, Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, Nascent MHC class I molecules associate with TAP via tapasin, namely the binding of peptide, preventing MHC class I/TAP association, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules, which binds the TAP complex and acts as a tapasin inhibitor, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding, which blocks the peptide-binding site of TAP, Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ABC17, ABCB2, ATP-binding cassette sub-family B member 2, Antigen peptide transporter 1, D6S114E, PSF-1, PSF1, Peptide supply factor 1, Peptide transporter PSF1, Peptide transporter TAP1, Peptide transporter involved in antigen processing 1, RING4, Really interesting new gene 4 protein, TAP1, TAP1*12N, TAP1N, Y3, APT1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Tap1 |
| Short name: |
Tap1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
adenosine triphosphate-binding cassette, sub-family B (multi-drug-resistant/TAP) (Antibody to), transporter 1 |
| Alternative technique: |
antibodies |
| Identity: |
39758 |
| Gene: |
PSMB8-AS1 |
More about : PSMB8-AS1 |
| Long gene name: |
PSMB8 antisense RNA 1 (head to head) |
| Synonyms gene: |
TAPSAR1 |
| Synonyms gene name: |
TAP1 and PSMB8 antisense RNA 1 |
| Synonyms: |
XXbac-BPG246D15, 8 TAP1-AS1 |
| Locus: |
6p21, 32 |
| Discovery year: |
2013-07-25 |
| Entrez gene record: |
100507463 |
| RefSeq identity: |
NR_037173 |
| Havana BLAST/BLAT: |
OTTHUMG00000140123 |