| Long name: |
Cy7 Conjugated, CK10 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy7 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CK10 |
| Specificity: |
13, 14, 15, 17 based on an 85% sequence similarity in the immunogen range, This antibody my have secondary cross-reactivities with Keratin 12, This is a highly specific antibody against CK10 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
140-190/584 |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human CK10 |
| Gene ID number: |
3858 |
| Swiss Prot: |
P13645 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560), AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens, At birth, Cytokeratin 10 is generally associated with keratin 1, Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum, It is seen in all suprabasal cell layers including stratum corneum, Transmission is autosomal dominant, Within a few weeks, affected individuals usually present with redness, also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq, also known as cyclic ichthyosis with epidermolytic hyperkeratosis, blisters and superficial erosions due to cytolysis, but most cases are sporadic, the erythroderma and blister formation diminish and hyperkeratoses develop, Cytokeratin 10 is a heterotetramer of two type I and two type II keratins |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
743nm/767nm |
| Synonyms: |
K10 CK10 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths |
| Gene target: |
CK10 Conjugated |
| Short name: |
Conjugated, CK10 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy7 |
| Alternative name: |
cyanine 7 coupled, CK10 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6413 |
| Gene: |
KRT10 |
More about : KRT10 |
| Long gene name: |
keratin 10 |
| Synonyms gene: |
KPP |
| Synonyms gene name: |
keratosis palmaris et plantaris keratin 10, type I |
| Synonyms name: |
cytokeratin 10 epidermolytic hyperkeratosis |
| Locus: |
17q21, 2 |
| Discovery year: |
1988-08-12 |
| GenBank acession: |
J04029 |
| Entrez gene record: |
3858 |
| Pubmed identfication: |
2461420 16831889 |
| RefSeq identity: |
NM_000421 |
| Classification: |
Keratins, type I |
| Havana BLAST/BLAT: |
OTTHUMG00000133368 |