| Long name: |
ALEXA FLUOR 488 Conjugated, CK10 Polyclonal Antibody |
| Also known as: |
Anti-CK10 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CK10 |
| Specificity: |
This is a highly specific antibody against CK10 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
140-190/584 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CK10 |
| Gene ID Number: |
3858 |
| Swiss Prot: |
P13645 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560), AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens, At birth, Cytokeratin 10 is generally associated with keratin 1, Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum, It is seen in all suprabasal cell layers including stratum corneum, Transmission is autosomal dominant, Within a few weeks, affected individuals usually present with redness, also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq, also known as cyclic ichthyosis with epidermolytic hyperkeratosis, blisters and superficial erosions due to cytolysis, but most cases are sporadic, the erythroderma and blister formation diminish and hyperkeratoses develop, Cytokeratin 10 is a heterotetramer of two type I and two type II keratins |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
K10 CK10 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the CK10 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
CK10 |
| Short name: |
CK10 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, CK10 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6413 |
| Gene: |
KRT10 |
More about : KRT10 |
| Long gene name: |
keratin 10 |
| Synonyms gene: |
KPP |
| Synonyms gene name: |
keratosis palmaris et plantaris keratin 10, type I |
| Synonyms name: |
cytokeratin 10 epidermolytic hyperkeratosis |
| Locus: |
17q21, 2 |
| Discovery year: |
1988-08-12 |
| GenBank acession: |
J04029 |
| Entrez gene record: |
3858 |
| Pubmed identfication: |
2461420 16831889 |
| RefSeq identity: |
NM_000421 |
| Classification: |
Keratins, type I |
| Havana BLAST/BLAT: |
OTTHUMG00000133368 |