| Long name: |
FITC Conjugated, ICOS/CD278 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
ICOS/CD278 |
| Specificity: |
This antibody may also have a secondary cross-reactivity with AP-1 complex-associated regulatory protein due to a 77% non-contiguous sequence similarity in the corresponding immunogen region, This is a highly specific antibody against ICOS/CD278 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
40-90/199 |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human ICOS |
| Gene ID number: |
29851 |
| Swiss Prot: |
Q9Y6W8 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Does not up-regulate the production of interleukin-2, Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens, Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity), Prevents the apoptosis of pre-activated T-cells, and effective help for antibody secretion by B-cells, but superinduces the synthesis of interleukin-10, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, Enhances all basic T-cell responses to a foreign antigen |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
AILIM CD278 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ICOS/CD278 Conjugated |
| Short name: |
FITC Conjugated, ICOS/CD278 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, inducible T-cell co-stimulator/CD278 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, ICOS and IDBG-643378 and ENSBTAG00000021596 and 507026, ICOS and IDBG-79246 and ENSG00000163600 and 29851, Icos and IDBG-159737 and ENSMUSG00000026009 and 54167, protein binding, this GO :0002517 and T cell tolerance induction and biological process this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0031295 and T cell costimulation and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, inducible T-cell co-stimulator |
| Identity: |
5351 |
| Gene: |
ICOS |
More about : ICOS |
| Long gene name: |
inducible T-cell costimulator |
| Synonyms name: |
activation-inducible lymphocyte immunomediatory molecule |
| Locus: |
2q33, 2 |
| Discovery year: |
2000-02-29 |
| GenBank acession: |
AB023135 |
| Entrez gene record: |
29851 |
| Pubmed identfication: |
9930702 10617205 |
| RefSeq identity: |
NM_012092 |
| Classification: |
CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000132880 |
| Locus Specific Databases: |
ICOSbase: Mutation registry for ICOS deficiency LRG_65 |