| Long name: |
CD163/M130 Primary Polyclonal Antibody |
| Also known as: |
CD163/M130 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CD163/M130 |
| Specificity: |
This is a highly specific antibody against CD163/M130 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
800-850/1156 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human CD163/M130 |
| Gene ID number: |
9332 |
| Swiss Prot: |
Q86VB7 |
| Tested Applications: |
FCM, IF(ICC), IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
FCM(1:20-100), IF(ICC)(1:50-200), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
After shedding, Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype, Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells, May play a role in the uptake and recycling of iron, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions, inositol triphosphate production and secretion of IL6 and CSF1, the soluble form (sCD163) may play an anti-inflammatory role, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme, Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD163, Hemoglobin scavenger receptor, MM13, Scavenger receptor cysteine-rich type 1 protein M13, M13 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CD163/M130 |
| Short name: |
CD163/M130 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CD163 molecule/M130 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD163 and IDBG-16292 and ENSG00000177575 and 9332, CD163 and IDBG-639861 and ENSBTAG00000019669 and 533844, Cd163 and IDBG-186721 and ENSMUSG00000008845 and 93671, Extracellular, M130 and MM130, protein binding, this GO :0005044 and scavenger receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006898 and receptor-mediated endocytosis and biological process this GO :0006953 and acute-phase response and biological process this GO :0016020 and membrane and cellular component this GO :0030666 and endocytic vesicle membrane and cellular component, this GO :0005044 : scavenger receptor activity, this GO :0005044 : scavenger receptor activity and also this GO :0005515 : protein binding, this GO :0005515 : protein binding, CD163 molecule |
| Identity: |
1631 |
| Gene: |
CD163 |
More about : CD163 |
| Long gene name: |
CD163 molecule |
| Synonyms gene name: |
CD163 antigen |
| Synonyms: |
M130 MM130 SCARI1 |
| Locus: |
12p13, 31 |
| Discovery year: |
2000-01-18 |
| GenBank acession: |
Z22968 |
| Entrez gene record: |
9332 |
| Pubmed identfication: |
10403791 8370408 |
| RefSeq identity: |
NM_004244 NM_203416 |
| Classification: |
CD molecules Scavenger receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000168353 |