| Long name: |
Cy3 Conjugated, Axin1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
cy3 conjugation kit |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Axin1 |
| Specificity: |
This is a highly specific antibody against Axin1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
830-862/862 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human Axin1 |
| Gene ID number: |
8312 |
| Swiss Prot: |
O15169 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, Controls dorsoventral patterning via two opposing effects, Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7, Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation, In Wnt signaling, Likely to function as a tumor suppressor, and modulating Wnt-signaling, apoptosis and development, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B, Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
512, 550nm/570, 615nm |
| Synonyms: |
AXIN1, Axin-1, Axis inhibition protein 1, PPP1R49, hAxin, AXIN |
| Properties: |
1 of the Axin1 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Axin1 Conjugated |
| Short name: |
Conjugated, Axin1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Cy3 |
| Alternative name: |
cyanine 3 coupled, axin 1 (Antibody to) |
| Alternative technique: |
antibodies |