| Long name: |
ALEXA FLUOR 488 Conjugated, Axin1 Polyclonal Antibody |
| Also known as: |
Anti-Axin1 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Axin1 |
| Specificity: |
This is a highly specific antibody against Axin1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
830-862/862 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Axin1 |
| Gene ID Number: |
8312 |
| Swiss Prot: |
O15169 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, Controls dorsoventral patterning via two opposing effects, Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7, Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation, In Wnt signaling, Likely to function as a tumor suppressor, and modulating Wnt-signaling, apoptosis and development, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway, down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B, Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
PPP1R49 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Axin1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Axin1 |
| Short name: |
Axin1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, axin 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
903 |
| Gene: |
AXIN1 |
More about : AXIN1 |
| Long gene name: |
axin 1 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 49 |
| Locus: |
16p13, 3 |
| Discovery year: |
1998-09-17 |
| GenBank acession: |
AF009674 |
| Entrez gene record: |
8312 |
| Pubmed identfication: |
9230313 |
| Classification: |
Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000064930 |